Endocrine Abstracts

Among the uncertainties surrounding the etiology of polycystic ovary syndrome (PCOS) the role of increased peripheral cortisol metabolism has become interesting, particularly in relationship to the pathogenesis of adrenal hyperandrogenism. The patways of cortisol metabolism include irreversible inactivation of cortisol by 5α- and 5β-reductase. To evaluate the association of 5α- and 5β-reductase activity with adrenal hyperandrogenism in PCOS, we recruited 90...

Aim: The purpose of the study was to evaluate the prevalence of the metabolic syndrome (MS) in a cohort of young Mediterranean women with PCOS in reproductive age and to evaluate the association of the MS with clinical and biochemical parameters.Setting: Among 200 PCOS (17-31 years) criteria of MS in accordance with the “NCEP-ATPIII” were used to construct 3 groups: no one criteria, 1 or 2 criteria and 3 or more criteria (affected by MS). All p...

Congenital morphological alteration of anterior and/or posterior pituitary lobes is a rare disease often associated with isolated or multiple hormonal deficiency. In this study we re-evaluated 24 adult patients, 20 males and 4 females, (23–46 years), in whom Nuclear Magnetic Resonance (NMR) showed congenital morphological alteration of the gland. Twenty out of 24 patients presented with an association of hypoplasic adenohypophysis and ectopic neurohypophysis, while 4 pres...

Introduction: Hypoparathyroidism (HP) is characterized by low serum calcium and increased phosphate levels associated with inappropriately low serum PTH levels. Clinical manifestations of HP are tingling, muscle cramps, seizures, nephrocalcinosis, kidney stone, kidney failure, depression and anxiety.Objective: Quantify the chronic symptoms and complications of HP in our monocentric cohort.Material and methods: We conducted a retros...

Objective: This study was aimed to evaluate the prevalence of non classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21-NCAH) in hyperandrogenic women in the reproductive age attending our Endocrinology Unit and to identify specific phenotypic traits among clinical, biochemical and hormonal features.Setting: Outpatient Unit of Endocrinology, S. Orsola-Malpighi University Hospital of Bologna, Italy.Patients a...

Introduction: Hypoparathyroidism (Hypo) is associated with a higher risk of chronic kidney disease (CKD) and renal stones, although the time to onset of these complications in the disease’s natural history has never been explored. Calcium-Phosphate product (CaxP) has been shown to be a risk factor for moderate renal disease in Hypo in a limited number of cross-sectional or case-control studies.Objective: To determine the time of onset of incident se...

Context: Numerous studies propose a potential role of PTH in uric acid (UA) metabolism, particularly through its impact on the ABCG2 transporter, which is responsible for UA excretion in the intestines and kidneys. Another suggested mechanism involves increased tubular reabsorption of UA due to hypercalcemia-induced extracellular volume contraction. Elevated UA levels constitute a well-established risk factor for cardiovascular disease, nephrolithiasis, and chronic kidney dise...

Importance: Adrenal insufficiency is a life-threatening condition complicating heterogenous disorders across various disciplines, with challenging diagnosis and a notable drug-induced component.Objective: To describe the spectrum and main features of drug-induced adrenal insufficiency through adverse drug event reports received by the Food and Drug Administration (FDA).Design: We conducted a retrospective disproportionality analysi...

Background: Evaluation of steroid replacement therapy (SRT) in adrenal insufficiency (AI) is challenging for the lack of reliable parameters. Measurement of salivary cortisol and cortisone emerged as a non-invasive tool for AI management, however poorly investigated. Aim: To analyse the cortisol and cortisone circadian rhythm in normal controls (NC) and patients with primary AI (PAI) under different SRTs, and to identify useful biomarkers. <p class="...

Background: Altered sleep quality and duration have been reported in 26-67% of patients with type 1 diabetes (T1D). However, differences in study designs, populations, and methods of sleep quality assessment have led to heterogeneous results in terms of association with clinical data and blood glucose parameters.Aims: To investigate the sleep quality of a large cohort of adult patients with autoimmune diabetes under insulin treatment, and to analyze the ...